RNA splicing

By Targets:	DNA/RNA Synthesis (6) ADC Cytotoxin (1) CDK (1) Huntingtin (1) iGluR (2)
By Research Areas:	Cancer (5) Inflammation/Immunology (4) Neurological Disease (2)

Targets Recommended: DNA/RNA Synthesis Small Interfering RNA (siRNA) SF3B1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-150247

RNA splicing modulator 2

DNA/RNA Synthesis Others

RNA splicing modulator 2 (compound 256) is a RNA splicing modulator .
HY-150246

RNA splicing modulator 1

DNA/RNA Synthesis Others

RNA splicing modulator 1 (compound 233) is a RNA splicing modulator, with an AC₅₀ value of <100 nM .
HY-150248

RNA splicing modulator 3

DNA/RNA Synthesis Others

RNA splicing modulator 3 (compound 236) is a RNA splicing modulator, with an AC₅₀ value of <100 nM .

RNA splicing modulator 2	DNA/RNA Synthesis	Others
RNA splicing modulator 2 (compound 256) is a RNA splicing modulator .

RNA splicing modulator 1	DNA/RNA Synthesis	Others
RNA splicing modulator 1 (compound 233) is a RNA splicing modulator, with an AC₅₀ value of <100 nM .

RNA splicing modulator 3	DNA/RNA Synthesis	Others
RNA splicing modulator 3 (compound 236) is a RNA splicing modulator, with an AC₅₀ value of <100 nM .

HY-148384A

UHMCP1 dihydrochloride	Others	Cancer
UHMCP1 dihydrochloride is a potent UHM domain splicing inhibitor with a K_d value of 79 µM. UHMCP1 dihydrochloride prevents the SF3b155/U2AF ⁶⁵ interaction. UHMCP1 dihydrochloride impacts cell viability and RNA splicing .

HY-148384

UHMCP1	Others	Cancer
UHMCP1 is a chemical probe of U2AF homology motifs (UHM) with a K_d of 79 μM. UHMCP1 prevents the SF3b155/U2AF65 interaction, impacts RNA splicing and cell viability. UHMCP1 has potential anticancer properties .

HY-148828

LSP-GR3	iGluR
LSP-GR3 is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.

HY-148828A

LSP-GR3 sodium	iGluR	Neurological Disease
LSP-GR3 sodium is a novel chemically-modified RNA oligonucleotides, called splice modulating oligomers (SMOs), which potently and specifically modulate GluR alternative splicing to GluR3-flip expression throughout the CNS.

HY-153736

NSC 194308	Others	Cancer
NSC 194308, a *U2AF2-RNA* complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations .

HY-112980

Nusinersen	DNA/RNA Synthesis	Inflammation/Immunology
Nusinersen is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein .

HY-112980A

Nusinersen sodium	DNA/RNA Synthesis	Inflammation/Immunology
Nusinersen sodium is an antisense oligonucleotide agent that modifies pre–messenger RNA splicing of the SMN2 gene and thus promotes increased production of full-length SMN protein .

HY-124648

SMN-C2	DNA/RNA Synthesis	Inflammation/Immunology
SMN-C2, an analog of RG-7916, is a selective modulator of SMN2 gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research .

HY-156103

mHTT-IN-2	Huntingtin	Neurological Disease
mHTT-IN-2 (compound 27) is a potent inhibitor (EC₅₀=0.066 μM) of mutant huntingtin (mHTT). mHTT-IN-2 reduces canonical splicing of HTT RNA exons [49-50] and is a splicing regulator of the huntingtin (HTT) gene. mHTT-IN-2 exhibits inhibitory activity in vitro and in vivo in human HD stem cells and mouse BACHD models. mHTT-IN-2 may be used in the study of branaplam-related peripheral neuropathy .

HY-122970

1,2-Dihydrotanshinone 1,2-Dihydrotanshinquinone	Others	Inflammation/Immunology
1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1 .

HY-155874

ZNL-05-044	CDK	Cancer
ZNL-05-044 is a CDK11 inhibitor with an IC₅₀s of 0.23 μM and 0.27 μM against CDK11A and CDK11B, respectively (NanoBRET assay). ZNL-05-044 leads to G2/M cell cycle arrest and impairs RNA splicing .

HY-129589

Thailanstatin A	ADC Cytotoxin	Cancer
Thailanstatin A is an ultra-potent inhibitor of eukaryotic **RNA splicing (IC₅₀**=650 nM). Thailanstatin A exerts effects via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low-nM to sub-nM IC₅₀s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding “linker-less” ADC .

Cat. No.	Product Name	Target	Research Area

HY-P5960

PTBP1-RNA-binding inhibitor P6 TFA PTBP1 α3-helix derived peptide P6 TFA	Peptides	Others
PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing factor PTBP1, which inhibits alternative splicing events regulated by PTBP1. PTBP1 binds RNA through its RNA recognition motif .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-122970

1,2-Dihydrotanshinone 1,2-Dihydrotanshinquinone	Classification of Application Fields Terpenoids Labiatae Source classification Samanea saman (Jacq.) Merr. Diterpenoids Plants Disease Research Fields Inflammation/Immunology	Others
1,2-Dihydrotanshinone (1,2-Dihydrotanshinquinone) is an abietane diterpene. 1,2-Dihydrotanshinone inhibits the formation of the pathogenic complex formed between (CUG)n-RNA and the splicing-factor muscleblind-like 1 (MBNL1). 1,2-Dihydrotanshinone can be used for the research of myotonic dystrophy type 1 .

Cat. No.	Compare	Product Name	Species	Source

HY-P77362

	ESRP1/RBM35A Protein, Human (sf9, His) Epithelial splicing regulatory protein 1; RNA-binding protein 35A; RBM35A	Human	Sf9 insect cells
	The ESRP1/RBM35A protein is an important mRNA splicing factor, particularly affecting epithelial cell-specific isoforms such as FGFR2-IIIb. During epithelial-mesenchymal transition (EMT), its regulatory influence extends to transcripts including CD44, CTNND1, and ENAH. ESRP1/RBM35A Protein, Human (sf9, His) is the recombinant human-derived ESRP1/RBM35A protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of ESRP1/RBM35A Protein, Human (sf9, His) is 681 a.a., with molecular weight of ~77.9 KDa.


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RNA splicing

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